Psychiatric genetics Lab
Our lab is interested in deciphering the molecular basis of mood and anxiety disorders. By combining psychiatric genetics, molecular pharmacology and transgenic animal models, we pursue aims focused toward unraveling the role of neurotransmitter system components implicated in these diseases. Our main goal is to identify novel targets for treatment of these devastating disorders that dramatically impact our health system and quality of life worldwide.
In our psychiatric genetics studies, we search for gene variants associated with Obsessive-Compulsive Disorders, Bipolar Disorder, Tourette Disorder, Schizophrenia and Epilepsy. We perform genotyping and functional studies of novel genetic variants. We follow both classic targets in monoamine neurotransmitter systems as well as novel gene candidates. We are also interested in epigenetic and transcriptome analyses. We also perform behavioral genetics to characterize in vivo novel candidate genes using animal models. Using transgenic technology and viral vectors, we manipulate genes in specific neuronal types and/or brain regions, and extensively characterize these models by behavioral phenotyping, molecular and neurochemical approaches. One of our current major efforts is to understand the role of novel candidate genes in Obsessive-Compulsive Disorder (OCD) and Bipolar Disorder, and how altered expression levels affect brain circuits at neurochemical and behavioral level.
Dr. Pablo Moya
Instituto de Fisiología, Facultad de Ciencias
Universidad de Valparaíso
Investigador del Centro de Neurobiología y Plasticidad Cerebral CNPC
Investigador del Centro Interdisciplinario de Neurociencias de Valparaíso CINV